Amyloidosis occurs when abnormal antibody proteins or other protein fragments build up in an organ. As the protein accumulates, organ function begins to decline. Amyloidosis can affect any organ. In its primary form, it is a serious but rare condition: only eight out of every million Americans are diagnosed every year. Its cause is unknown.Amyloid Antibodies and Bone Marrow The proteins that accumulate in organs... Read more >
Amyloid deposits cause a number of common and rare diseases. Some, such as Alzheimer's disease and type 2 diabetes, are well-known disorders. Others, such as multiple myeloma and familial Mediterranean fever, are rare and relatively unknown to the general public.Primary Amyloidosis and Multiple MyelomaPrimary amyloidosis is also called amyloid light chain, or AL. AL is associated with plasma cell disorders, rare... Read more >
Amyloidosis often has no symptoms in its early stages. Symptoms develop only after protein deposits begin to interfere with organ function. Amyloidosis symptoms are usually a function of the organs that are affected. Accordingly, signs of the disease are varied, making diagnosis difficult.Proteinuria and Kidney Failure Often, the first sign of amyloidosis is a positive proteinuria result on a standard urine test... Read more >
No cure has been found for amyloidosis. Treatment consists of slowing disease progression, treating underlying causes, and reducing symptoms. Because of the wide range of organs susceptible to protein buildup, treatment must be individualized according to causes and symptoms.Biopsy Samples and Pathology Results A diagnosis of amyloidosis often begins when routine tests reveal high levels of protein in the urine... Read more >
Amyloidosis Support Network. (Updated 2003). What is amyloidosis? Retrieved June 2, 2003, fromamyloidosis.org.Amyloidosis Support Network. (Updated 2003). Overview of primary systemic AL amyloidosis. Retrieved June 3, 2003, fromamyloidosis.org/alsummary.asp.Beers, M. H., & Berkow, R. (ed). (1999). Amyloidosis [electronic version], The Merck Manual of Diagnosis and Therapy, 17th Edition. Merck Research... Read more >
Amyloidosis and Alzheimer’s disease appear to be related, sharing some important clinical features and symptoms. To fully understand the connection between the two diseases, it is necessary to understand both amyloidosis and Alzheimer’s disease. About Amyloidosis What is amyloidosis? Essentially, amyloidosis is a disease caused by the buildup of abnormal protein deposits, amyloids, in the body. Amyloidosis... Read more >
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